Sjogren's Syndrome
May 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Salivary gland ultrasound integrated with 2016 ACR/EULAR classification criteria improves the diagnosis of primary Sjögren's syndrome.
Authors:Geng Y, Li B, Deng X, Ji L, Zhang X, Zhang Z
Institution:Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.
Journal:Clin Exp Rheumatol. 2020 Mar-Apr;38(2):322-328. Epub 2020 Jan 27.

2:Disease activity and damage in patients with primary Sjogren's syndrome: Prognostic value of salivary gland ultrasonography.
Authors:Milic V, Colic J, Cirkovic A, Stanojlovic S, Damjanov N
Institution:Institute of Rheumatology, Belgrade, Serbia.
Journal:PLoS One. 2019 Dec 31;14(12):e0226498. doi: 10.1371/journal.pone.0226498. eCollection 2019.

3:Oral lesions in patients with primary Sjögren's syndrome. A case-control cross-sectional study.
Authors:Serrano J, López-Pintor RM, Fernández-Castro M, Ramírez L, Sanz M, Casañas E, García JA, Recuero S, Bohorquez C, Hernández G
Institution:Departamento de Especialidades Clinicas Odontologicas Facultad de Odontologia Universidad Complutense de Madrid Plaza Ramon y Cajal s/n, 28040 Madrid. Spain
Journal:Med Oral Patol Oral Cir Bucal. 2020 Jan 1;25(1):e137-e143. doi: 10.4317/medoral.23254.

4:Clinical, morphological features and prognostic factors associated with interstitial lung disease in primary Sjӧgren's syndrome: A systematic review from the Italian Society of Rheumatology.
Authors:Sambataro G, Ferro F, Orlandi M, Sambataro D, Torrisi SE, Quartuccio L, Vancheri C, Baldini C, Matucci Cerinic M
Institution:Artroreuma S.R.L., Rheumatology Outpatient Clinic Accredited with the Italian National Health System, Corso S. Vito 53, 95030 Mascalucia, (CT), Italy; Regional Referral Centre for Rare Lung Diseases, A Department of Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Italy.
Journal:Autoimmun Rev. 2020 Feb;19(2):102447. doi: 10.1016/j.autrev.2019.102447. Epub 2019 Dec 14.

5:Patient-related outcomes in Sjögren syndrome treated with stimulants of salivary secretion: Randomized clinical trial.
Authors:da Mata ADSP, Amaral JPAR, Thomson WM, Barcelos F, Vaz Patto J, Pereira RMN, Marques DNDS
Institution:Oral Biology & Biochemistry Research Group, LIBPhys-FCT UID/FIS/04559/2013, Faculdade de Medicina Dentaria, Universidade de Lisboa, Lisboa, Portugal.
Journal:Oral Dis. 2020 Mar;26(2):313-324. doi: 10.1111/odi.13251. Epub 2019 Dec 26.

6:Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren's syndrome.
Authors:Brito-Zerón P, Retamozo S, Kostov B, Baldini C, Bootsma H, De Vita S, Dörner T, Gottenberg JE, Kruize AA, Mandl T, Ng WF, Seror R, Tzioufas AG, Vitali C, Bowman S, Mariette X, Ramos-Casals M
Institution:Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA-Sanitas, Barcelona, Spain. Laboratory of Autoimmune Diseases Josep Font, CELLEX, IDIBAPS, Barcelona, Spain.
Journal:RMD Open. 2019 Oct 28;5(2):e001064. doi: 10.1136/rmdopen-2019-001064. eCollection 2019.

7:Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren's syndrome patients: A nationwide population-based study.
Authors:Lee CK, Tsai CP, Liao TL, Huang WN, Chen YH, Lin CH, Chen YM
Institution:Department of Medical Education, Taichung Veterans General Hospital, Taichung, Taiwan. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Journal:PLoS One. 2019 Nov 20;14(11):e0225455. doi: 10.1371/journal.pone.0225455. eCollection 2019.

8:Quantitative assessment of interstitial lung disease in Sjögren's syndrome.
Authors:Guisado-Vasco P, Silva M, Duarte-Millán MA, Sambataro G, Bertolazzi C, Pavone M, Martín-Garrido I, Martín-Segarra O, Luque-Pinilla JM, Santilli D, Sambataro D, Torrisi SE, Vancheri A, Gutiérrez M, Mejia M, Palmucci S, Mozzani F, Rojas-Serrano J, Vanchieri C, Sverzellati N, Ariani A
Institution:Internal Medicine, Complejo hospitalario Ruber Juan Bravo, Universidad Europea (Madrid), Madrid, Spain. Internal Medicine and Rheumatoloy Unit, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Journal:PLoS One. 2019 Nov 8;14(11):e0224772. doi: 10.1371/journal.pone.0224772. eCollection 2019.

9:EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.
Authors:Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X
Institution:Department of Autoimmune Diseases, Hospital Clinic de Barcelona Institut Clinic de Medicina i Dermatologia, Barcelona, Catalunya, Spain Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR 1184, Universite Paris Sud, Universite Paris-Saclay, Paris, France.
Journal:Ann Rheum Dis. 2020 Jan;79(1):3-18. doi: 10.1136/annrheumdis-2019-216114. Epub 2019 Oct 31.

10:Pulmonary involvement in primary Sjögren's syndrome, as measured by the ESSDAI.
Authors:Heus A, Arends S, Van Nimwegen JF, Stel AJ, Nossent GD, Bootsma H
Institution:Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Journal:Scand J Rheumatol. 2020 Jan;49(1):38-46. doi: 10.1080/03009742.2019.1634221. Epub 2019 Sep 26.

11:Increased risks of psychiatric disorders in patients with primary Sjögren's syndrome-a secondary cohort analysis of nationwide, population-based health claim data.
Authors:Hsieh MC, Hsu CW, Lu MC, Koo M
Institution:Division of Obstetrics and Gynecology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan. Graduate Institute of Long-term Care, Tzu Chi University of Science and Technology, Hualien, Taiwan.
Journal:Clin Rheumatol. 2019 Nov;38(11):3195-3203. doi: 10.1007/s10067-019-04705-z. Epub 2019 Aug 1.

12:Effectiveness of resistance exercise in functional fitness in women with primary Sjögren's syndrome: randomized clinical trial.
Authors:Minali PA, Pimentel C, de Mello MT, Lima G, Dardin LP, Garcia A, Goñi T, Trevisani V
Institution:Department of Medicine, Discipline of Health-Based Evidence, Federal University of Sao Paulo, Sao Paulo, Brazil.
Journal:Scand J Rheumatol. 2020 Jan;49(1):47-56. doi: 10.1080/03009742.2019.1602880. Epub 2019 Jun 27.

13:Hydroxychloroquine was associated with reduced risk of new-onset diabetes mellitus in patients with Sjögren syndrome.
Authors:Chen TH, Lai TY, Wang YH, Chiou JY, Hung YM, Wei JC
Institution:School of Medicine, Chung Shan Medical University, Taichung, Taiwan. Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Journal:QJM. 2019 Oct 1;112(10):757-762. doi: 10.1093/qjmed/hcz112.

14:Evaluation of the Efficacy and Safety of A Novel 0.05% Cyclosporin A Topical Nanoemulsion in Primary Sjögren's Syndrome Dry Eye.
Authors:Kang MJ, Kim YH, Chou M, Hwang J, Cheon EJ, Lee HJ, Chung SH
Institution:Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Journal:Ocul Immunol Inflamm. 2020 Apr 2;28(3):370-378. doi: 10.1080/09273948.2019.1587470. Epub 2019 Apr 15.

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