Sjogren's Syndrome
October 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study.
Authors:Wu MC, Xu X, Chen SM, Tyan YS, Chiou JY, Wang YH, Lin LC, Chen CM, Wei JC
Institution:School of Medicine, Chung Shan Medical University, Taichung, Taiwan. Taiwan. Taiwan. Taiwan. University, Nanjing, China. Taiwan. Taiwan. University, Taichung, Taiwan. Taiwan. Taiwan. Hospital; Taichung, Taiwan. America.
Journal:PLoS One. 2017 Jul 13;12(7):e0175836. doi: 10.1371/journal.pone.0175836. eCollection 2017.

2:Association between a history of mycobacterial infection and the risk of newly diagnosed Sjogren's syndrome: A nationwide, population-based case-control study.
Authors:Chao WC, Lin CH, Liao TL, Chen YM, Chen DY, Chen HH
Institution:Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Business Administration, National Changhua University of Education, Changhua, Taiwan.; Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan.; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Journal:PLoS One. 2017 May 9;12(5):e0176549. doi: 10.1371/journal.pone.0176549. eCollection 2017.

3:Complications of Sialendoscopy in Patients With Sjogren Syndrome.
Authors:Karagozoglu KH, De Visscher JG, Forouzanfar T, van der Meij EH, Jager DJ
Institution:Consultant Oral and Maxillofacial Surgeon and PhD Candidate, Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: Pathology, VU University Medical Center, Amsterdam; Department of Oral and Maxillofacial Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands. Oral Pathology, VU University Medical Center, Amsterdam, The Netherlands. Leeuwarden, Leeuwarden, The Netherlands. Pathology, VU University Medical Center; Center for Special Care Dentistry (SBT), Amsterdam, The Netherlands.
Journal:J Oral Maxillofac Surg. 2017 May;75(5):978-983. doi: 10.1016/j.joms.2016.09.046. Epub 2016 Oct 6.

4:Impact of pain on cognitive functions in primary Sjogren syndrome with small fiber neuropathy: 10 cases and a literature review.
Authors:Indart S, Hugon J, Guillausseau PJ, Gilbert A, Dumurgier J, Paquet C, Sene D
Institution:aCognitive Neurology Center AP-HP, Hopital Lariboisiere bINSERM, U942 cUniversity of Paris Diderot, Sorbonne Paris Cite dDepartment of Internal Medicine, AP-HP, Hopital Lariboisiere, INSERM eDepartment of Biochemistry and Molecular Biology, AP-HP, Hopital Lariboisiere, Paris, France.
Journal:Medicine (Baltimore). 2017 Apr;96(16):e6384. doi: 10.1097/MD.0000000000006384.

5:Fibromyalgia in 300 adult index patients with primary immunodeficiency.
Authors:Barton JC, Bertoli LF
Institution:Department of Medicine, Brookwood Medical Center, Birmingham, AL; Southern Iron Disorders Center, Birmingham, AL; and Department of Medicine, University of Alabama at Birmingham, AL, USA. Disorders Center, Birmingham, AL; and Brookwood Biomedical, Birmingham, AL, USA. University of Alabama at Birmingham, USA.
Journal:Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):68-73. Epub 2017 Apr 19.

6:Reviewing primary Sjogren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment.
Authors:Both T, Dalm VA, van Hagen PM, van Daele PL
Institution:Department of Internal Medicine, Division of Clinical Immunology.; Department of Internal Medicine, Division of Clinical Immunology;; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Journal:Int J Med Sci. 2017 Feb 23;14(3):191-200. doi: 10.7150/ijms.17718. eCollection 2017.

7:One year in review 2017: primary Sjogren's syndrome.
Authors:Ferro F, Marcucci E, Orlandi M, Baldini C, Bartoloni-Bocci E
Institution:Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy. of Florence, Italy. of Pisa, Italy.
Journal:Clin Exp Rheumatol. 2017 Mar-Apr;35(2):179-191. Epub 2017 Mar 15.

8:Randomized Controlled Trial of Rituximab and Cost-Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjogren's Syndrome.
Authors:Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng WF, Pease CT, Price EJ, Sutcliffe N, Gendi NST, Hall FC, Ruddock SP, Fernandez C, Reynolds C, Hulme CT, Davies KA, Edwards CJ, Lanyon PC, Moots RJ, Roussou E, Giles IP, Sharples LD, Bombardieri M
Institution:University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Journal:Arthritis Rheumatol. 2017 Jul;69(7):1440-1450. doi: 10.1002/art.40093. Epub 2017 Jun 5.

9:Fibromyalgia prevalence and associated factors in primary Sjogren's syndrome patients in a large cohort from the Spanish Society of Rheumatology registry (SJOGRENSER).
Authors:Torrente-Segarra V, Corominas H, Sanchez-Piedra C, Fernandez-Castro M, Andreu JL, Martinez-Taboada VM, Olive A, Rosas J, Sanchez-Alonso F
Institution:Rheumatology Department, Hospital General Hospitalet-Moises Broggi, Barcelona, Spain. Spain. Madrid,Spain. Madrid, Spain.
Journal:Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):28-34. Epub 2017 Feb 24.

10:It's more than dryness and fatigue: The patient perspective on health-related quality of life in Primary Sjogren's Syndrome - A qualitative study.
Authors:Lackner A, Ficjan A, Stradner MH, Hermann J, Unger J, Stamm T, Stummvoll G, Dur M, Graninger WB, Dejaco C
Institution:Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University Graz, Graz, Austria. University Graz, Graz, Austria. University Graz, Graz, Austria. University Graz, Graz, Austria. of Occupational Therapy, Bad Gleichenberg, Austria. Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Vienna, Austria. University Graz, Graz, Austria. University Graz, Graz, Austria. Italy.
Journal:PLoS One. 2017 Feb 9;12(2):e0172056. doi: 10.1371/journal.pone.0172056. eCollection 2017.

11:Effect of Tobacco Smoking on The Clinical, Histopathological, and Serological Manifestations of Sjogren's Syndrome.
Authors:Stone DU, Fife D, Brown M, Earley KE, Radfar L, Kaufman CE, Lewis DM, Rhodus NL, Segal BM, Wallace DJ, Weisman MH, Venuturupalli S, Brennan MT, Lessard CJ, Montgomery CG, Scofield RH, Sivils KL, Rasmussen A
Institution:Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland, United States of America.; King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.; US Air Force 59th Medical Wing, Joint Base San Antonio-Lackland Air Force Base, San Antonio, Texas, United States of America.; Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma, United States of America.
Journal:PLoS One. 2017 Feb 6;12(2):e0170249. doi: 10.1371/journal.pone.0170249. eCollection 2017.

12:Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjogren's Syndrome According to Ancestry.
Authors:Taylor KE, Wong Q, Levine DM, McHugh C, Laurie C, Doheny K, Lam MY, Baer AN, Challacombe S, Lanfranchi H, Schiodt M, Srinivasan M, Umehara H, Vivino FB, Zhao Y, Shiboski SC, Daniels TE, Greenspan JS, Shiboski CH, Criswell LA
Institution:University of California, San Francisco. UK.
Journal:Arthritis Rheumatol. 2017 Jun;69(6):1294-1305. doi: 10.1002/art.40040. Epub 2017 May 9.

13:Physical activity but not sedentary activity is reduced in primary Sjogren's syndrome.
Authors:Ng WF, Miller A, Bowman SJ, Price EJ, Kitas GD, Pease C, Emery P, Lanyon P, Hunter J, Gupta M, Giles I, Isenberg D, McLaren J, Regan M, Cooper A, Young-Min SA, McHugh N, Vadivelu S, Moots RJ, Coady D, MacKay K, Dasgupta B, Sutcliffe N, Bombardieri M, Pitzalis C, Griffiths B, Mitchell S, Miyamoto ST, Trenell M
Institution:Musculoskeletal Research Group, Institute of Cellular Medicine and NIHR Biomedical Research Centre for Ageing and Chronic Disease, Newcastle University, Newcastle upon Tyne, UK.; MoveLab, Physical Activity and Exercise Research, Institute of Cellular Medicine and NIHR Biomedical Research Centre for Ageing and Chronic Disease, Newcastle University, Newcastle upon Tyne, UK.; University Hospital Birmingham, Birmingham, UK.; Great Western Hospitals NHS Foundation Trust, Swindon, UK.; Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Dudley, UK.
Journal:Rheumatol Int. 2017 Apr;37(4):623-631. doi: 10.1007/s00296-016-3637-6. Epub 2016 Dec 24.

14:An investigation into the prevalence of sleep disturbances in primary Sjogren's syndrome: a systematic review of the literature.
Authors:Hackett KL, Gotts ZM, Ellis J, Deary V, Rapley T, Ng WF, Newton JL, Deane KHO
Institution:Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases. Northumbria University. Research Centre for Ageing and Chronic Diseases. Chronic Diseases, Newcastle upon Tyne.
Journal:Rheumatology (Oxford). 2017 Apr 1;56(4):570-580. doi: 10.1093/rheumatology/kew443.

15:A multicentre study of 95 biopsy-proven cases of renal disease in primary Sjogren's syndrome.
Authors:Jasiek M, Karras A, Le Guern V, Krastinova E, Mesbah R, Faguer S, Jourde-Chiche N, Fauchais AL, Chiche L, Dernis E, Moulis G, Fraison JB, Lazaro E, Jullien P, Hachulla E, Le Quellec A, Remy P, Hummel A, Costedoat-Chalumeau N, Ronco P, Vanhille P, Meas-Yedid V, Cordonnier C, Ferlicot S, Daniel L, Seror R, Mariette X, Thervet E, Francois H, Terrier B
Institution:Department of Nephrology, Hopital Bicetre, Assistance Publique-Hopitaux de Paris, Universite Paris-Sud, Le Kremlin-Bicetre.; Department of Nephrology, Hopital Europeen Georges Pompidou, AP-HP.; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hopital Cochin, AP-HP, Universite Paris Descartes, Paris.; Department of Epidemiology and Statistics, Hopital Bicetre, AP-HP, Universite Paris-Sud, Le Kremlin-Bicetre.; Department of Nephrology, Centre Hospitalier, Boulogne-Sur-Mer.
Journal:Rheumatology (Oxford). 2017 Mar 1;56(3):362-370. doi: 10.1093/rheumatology/kew376.

16:Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium.
Authors:Brito-Zeron P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Theander E, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Kruize AA, Valim V, Kvarnstrom M, Sene D, Gerli R, Praprotnik S, Isenberg D, Solans R, Rischmueller M, Kwok SK, Nordmark G, Suzuki Y, Giacomelli R, Devauchelle-Pensec V, Bombardieri M, Hofauer B, Bootsma H, Brun JG, Fraile G, Carsons SE, Gheita TA, Morel J, Vollenveider C, Atzeni F, Retamozo S, Horvath IF, Sivils K, Mandl T, Sandhya P, De Vita S, Sanchez-Guerrero J, van der Heijden E, Trevisani VFM, Wahren-Herlenius M, Mariette X, Ramos-Casals M
Institution:Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona, Spain. Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clinic, Barcelona, Spain. University, Istanbul, Turkey. Debrecen, Hungary. Foundation, Oklahoma City, Oklahoma, USA. Publique-Hopitaux de Paris, Hopitaux Universitaires Paris-Sud, Le Kremlin-Bicetre, Universite Paris Sud, INSERM U1184, Paris, France. Sweden. China. Strasbourg, CNRS, Strasbourg, France. Hospital, Vellore, India. Hospital "Santa Maria della Misericordia", Udine, Italy. Sapienza University of Rome, Rome, Italy.
Journal:Ann Rheum Dis. 2017 Jun;76(6):1042-1050. doi: 10.1136/annrheumdis-2016-209952. Epub 2016 Nov 29.

17:Severe Health-Related Quality of Life Impairment in Active Primary Sjogren's Syndrome and Patient-Reported Outcomes: Data From a Large Therapeutic Trial.
Authors:Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puechal X, Le Guern V, Sibilia J, Gottenberg JE, Chiche L, Hachulla E, Yves Hatron P, Goeb V, Hayem G, Morel J, Zarnitsky C, Dubost JJ, Saliou P, Pers JO, Seror R, Saraux A
Institution:Centre Hospitalier Universitaire de la Cavale Blanche, and EA 2216, INSERM ESPRI, ERI29, Universite de Brest, LabEx IGO, Brest, France.; Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires Paris-Sud, INSERM U1184, Universite Paris-Sud, Le Kremlin Bicetre, France.; Hotel-Dieu, Centre Hospitalier Universitaire Nantes, Nantes, France.; Centre Hospitalier Universitaire, Hopital Sud, Rennes, France.; Hopital Cochin, Paris, France.
Journal:Arthritis Care Res (Hoboken). 2017 Apr;69(4):528-535. doi: 10.1002/acr.22974.

18:Treatment Guidelines for Rheumatologic Manifestations of Sjogren's Syndrome: Use of Biologic Agents, Management of Fatigue, and Inflammatory Musculoskeletal Pain.
Authors:Carsons SE, Vivino FB, Parke A, Carteron N, Sankar V, Brasington R, Brennan MT, Ehlers W, Fox R, Scofield H, Hammitt KM, Birnbaum J, Kassan S, Mandel S
Institution:Winthrop-University Hospital Campus, State University of New York, Stony Brook, Mineola. Foundation, and Oklahoma City Department of Veterans Affairs Medical Center, Oklahoma City. Hempstead, New York.
Journal:Arthritis Care Res (Hoboken). 2017 Apr;69(4):517-527. doi: 10.1002/acr.22968. Epub 2017 Mar 3.

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