May 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Effect of evidence-based nursing intervention on upper limb function in postoperative radiotherapy patients with breast cancer.
Authors:Wang X, Lai Q, Tian Y, Zou L
Institution:Cancer Center Union Hospital, Tongji Medical College. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal:Medicine (Baltimore). 2020 Mar;99(11):e19183. doi: 10.1097/MD.0000000000019183.

2:First-in-human robotic supermicrosurgery using a dedicated microsurgical robot for treating breast cancer-related lymphedema: a randomized pilot trial.
Authors:van Mulken TJM, Schols RM, Scharmga AMJ, Winkens B, Cau R, Schoenmakers FBF, Qiu SS, van der Hulst RRWJ
Institution:Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Journal:Nat Commun. 2020 Feb 11;11(1):757. doi: 10.1038/s41467-019-14188-w.

3:Assessing Arm Volume in People During and After Treatment for Breast Cancer: Reliability and Convergent Validity of the LymphaTech System.
Authors:Binkley JM, Weiler MJ, Frank N, Bober L, Dixon JB, Stratford PW
Institution:TurningPoint Breast Cancer Rehabilitation, 8010 Roswell Road, Suite 120, Atlanta, GA 30350 (USA); and Oncology Rehabilitation Consultant, Atlanta, Georgia. School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Journal:Phys Ther. 2020 Mar 10;100(3):457-467. doi: 10.1093/ptj/pzz175.

4:Lymphedema Signs, Symptoms, and Diagnosis in Women Who Are in Minority and Low-Income Groups and Have Survived Breast Cancer.
Authors:Flores AM, Nelson J, Sowles L, Stephenson RG, Robinson K, Cheville A, Sander AP, Blot WJ
Institution:Departments of Physical Therapy and Human Movement Sciences and Medical Social Sciences, Northwestern University, Chicago, Illinois; Cancer Survivorship Institute, Robert H. Lurie Comprehensive Cancer International Epidemiology Institute, Rockville, Maryland; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Journal:Phys Ther. 2020 Mar 10;100(3):487-499. doi: 10.1093/ptj/pzaa002.

5:Lower extremity lymphedema in patients with gynecologic malignancies.
Authors:Dessources K, Aviki E, Leitao MM Jr
Institution:Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA
Journal:Int J Gynecol Cancer. 2020 Feb;30(2):252-260. doi: 10.1136/ijgc-2019-001032. Epub 2020 Jan 7.

6:Staging and clinical correlations of lymphoscintigraphy for unilateral gynecological cancer-related lymphedema.
Authors:Pappalardo M, Lin C, Ho OA, Kuo CF, Lin CY, Cheng MH
Institution:Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Journal:J Surg Oncol. 2020 Mar;121(3):422-434. doi: 10.1002/jso.25817. Epub 2019 Dec 25.

7:GOG 244-The lymphedema and gynecologic cancer (LEG) study: Incidence and risk factors in newly diagnosed patients.
Authors:Carlson JW, Kauderer J, Hutson A, Carter J, Armer J, Lockwood S, Nolte S, Stewart BR, Wenzel L, Walker J, Fleury A, Bonebrake A, Soper J, Mathews C, Zivanovic O, Richards WE, Tan A, Alberts DS, Barakat RR
Institution:Cancer Research for the Ozarks, 1235 E. Cherokee, Springfield, MO, 65804, USA. Electronic address: Northwell Health Cancer Institute, 1111 Marcus Avenue, New Hyde Park, NY, 11042, USA. Electronic address:
Journal:Gynecol Oncol. 2020 Feb;156(2):467-474. doi: 10.1016/j.ygyno.2019.10.009. Epub 2019 Dec 16.

8:Patient-reported outcomes after surgery for endometrial carcinoma: Prevalence of lower-extremity lymphedema after sentinel lymph node mapping versus lymphadenectomy.
Authors:Leitao MM Jr, Zhou QC, Gomez-Hidalgo NR, Iasonos A, Baser R, Mezzancello M, Chang K, Ward J, Chi DS, Long Roche K, Sonoda Y, Brown CL, Mueller JJ, Gardner GJ, Jewell EL, Broach V, Zivanovic O, Dowdy SC, Mariani A, Abu-Rustum NR
Institution:Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, NY, NY, USA; Department of Obstetrics and Gynecology, Weill Cornell Medical College, NY, NY, USA. Electronic address:
Journal:Gynecol Oncol. 2020 Jan;156(1):147-153. doi: 10.1016/j.ygyno.2019.11.003. Epub 2019 Nov 25.

9:What are the economic burden and costs associated with the treatment of breast cancer-related lymphoedema? A systematic review.
Authors:De Vrieze T, Nevelsteen I, Thomis S, De Groef A, Tjalma WAA, Gebruers N, Devoogdt N
Institution:Research Group for Rehabilitation in Internal Disorders, Department of Rehabilitation Sciences, KU Leuven - Catholic University of Leuven, O&N IV Herestraat 49, box 1510, 3000, Leuven, Belgium. tessa.d
Journal:Support Care Cancer. 2020 Feb;28(2):439-449. doi: 10.1007/s00520-019-05101-8. Epub 2019 Oct 28.

10:Regular Compression Therapy May Not Be Necessary for Lymphedema in Arms without a Subcutaneous Echo-Free Space.
Authors:Suehiro K, Morikage N, Harada T, Samura M, Nagase T, Mizoguchi T, Hamano K
Institution:Division of Vascular Surgery, Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. Electronic address:
Journal:Ann Vasc Surg. 2020 Jan;62:258-262. doi: 10.1016/j.avsg.2019.04.020. Epub 2019 Sep 5.

11:Review of preclinical and clinical studies of using cell-based therapy for secondary lymphedema.
Authors:Chen CE, Chiang NJ, Perng CK, Ma H, Lin CH
Institution:Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal:J Surg Oncol. 2020 Jan;121(1):109-120. doi: 10.1002/jso.25661. Epub 2019 Aug 5.

12:Delayed primary retention suture for inset of vascularized submental lymph node flap for lower extremity lymphedema.
Authors:Koide S, Lin CY, Cheng MH
Institution:Department of Plastic and Reconstrucitve Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.
Journal:J Surg Oncol. 2020 Jan;121(1):138-143. doi: 10.1002/jso.25520. Epub 2019 Jul 5.

13:Clinical features, microbiological epidemiology and recommendations for management of cellulitis in extremity lymphedema.
Authors:Rodriguez JR, Hsieh F, Huang CT, Tsai TJ, Chen C, Cheng MH
Institution:Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Journal:J Surg Oncol. 2020 Jan;121(1):25-36. doi: 10.1002/jso.25525. Epub 2019 Jul 2.

14:Long-term outcome of lower extremity lymphedema treated with vascularized lymph node flap transfer with or without venous complications.
Authors:Koide S, Lin CY, Chen C, Cheng MH
Institution:Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University and Medical College, Taoyuan, Taiwan.
Journal:J Surg Oncol. 2020 Jan;121(1):129-137. doi: 10.1002/jso.25602. Epub 2019 Jun 27.

15:Lymphoscintigraphy for the diagnosis of extremity lymphedema: Current controversies regarding protocol, interpretation, and clinical application.
Authors:Pappalardo M, Cheng MH
Institution:Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Journal:J Surg Oncol. 2020 Jan;121(1):37-47. doi: 10.1002/jso.25526. Epub 2019 Jun 18.

16:Impact of breast cancer-related lymphedema on working women.
Authors:Vignes S, Fau-Prudhomot P, Simon L, Sanchez-Bréchot ML, Arrault M, Locher F
Institution:Department of Lymphology, Hopital Cognacq-Jay, 15, rue Eugene-Millon, 75015, Paris, France.
Journal:Support Care Cancer. 2020 Jan;28(1):79-85. doi: 10.1007/s00520-019-04804-2. Epub 2019 Apr 13.

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